CAS number(s): 55818-57- . Many of these studies addressed how the body disposes of or metabolizes BPA. [92] It is primarily a river pollutant,[93] but has also been observed in the marine environment,[94] in soils,[95] and lower levels can also be detected in air. 25085-99-8) Suppliers Limit companies to: Worldwide USA China India EMAIL INQUIRY to 13 suppliers BOC Sciences | Address: Ramsey Road, Shirley, New York 11967, USA https://www.bocsci.com | Send Inquiry | Phone: +1- (631)-485-4226 BOC Sciences is a brand of BOCSCI Inc. Toxicol Sci. Bisphenol A (BPA) is a chemical produced in large quantities for use primarily in the production of polycarbonate plastics. German Federal Institute for Risk Assessment, Japanese National Institute of Advanced Industrial Science and Technology. PBE can be used as a reinforcing polymer on nanotubes and nanoparticles which can be useful in electronics, optical and aerospace based applications. [11]. BPA is also found in epoxy resins, which act as a protective lining on the inside of some metal-based food and beverage cans. The IUPAC name for an epoxide group is an oxirane.. Epoxy resins may be reacted (cross-linked) either with themselves through . About 2530% of all BPA is used in the manufacture of epoxy resins and vinyl ester resins. Toxicol Lett. Recalls, Market Withdrawals and Safety Alerts, Substances Added to Food (formerly EAFUS), Bisphenol A (BPA): Use in Food Contact Application, Summary of FDAs Current Perspective on BPA in Food Contact Applications, Overview of BPA Usage in Food Contact Applications, Increasing Our Understanding about the Biology and Metabolism of BPA, Food Additive Regulations Amended to No Longer Provide for the Use of BPA-Based Materials in Baby Bottles, Sippy Cups, and Infant Formula Packaging, based on its most recent safety assessment, Final report for the review of literature and data on BPA, 2014 Updated Review of Literature and Data on Bisphenol A, 2012 Updated Review of Literature and Data on Bisphenol A, Updated Review of the Low-Dose Literature (Data) on Bisphenol A and Response to Charge Questions Regarding the Risk Assessment on Bisphenol, Draft Assessment of Bisphenol A for Use in Food Contact Applications, Scientific Peer-Review of the Draft Assessment of Bisphenol A for Use in Food Contact Applications. (2013) A new approach to synergize academic and guideline-compliant research: the CLARITY-BPA research program. In recent years, many claims have been made about the health effects of BPA. The results of the independent evaluations were released in April 2010, as FDA made the CFSAN report and other relevant information available for public comment. These materials are much more common but their BPA content will be low. Chemical Name: Hydrogenated Bisphenol A Epoxy Resin CAS No. Properties of copolymer epoxy resins. If you are giving a presentation about an environmental health topic or Found that primates (including humans) of all ages effectively metabolize and excrete BPA much more rapidly and efficiently than rodents. Phenol is a man-made chemical, although it is also found naturally in animal waste and decomposing organic material. [5] https://www.regulations.gov/docket/FDA-2010-N-0100. Also, learn about different types of resins available and how to further improve their properties. 2012 May-Jun;34(3):331-7. l) Patterson TA, Twaddle NC, Roegge CS, Callicott RJ, Fisher JW, Doerge DR. Concurrent determination of bisphenol A pharmacokinetics in maternal and fetal rhesus monkeys. Name: Bisphenol A epoxy diacrylate . [103], BPA is an environmental contaminant of emerging concern. Epoxy resins made with BPA are tough and readily adhere to metal surfaces, making them excellent materials for protective coatings. You can also browse global suppliers,vendor,prices,Price,manufacturers of Bisphenol A epoxy resin(). Its chemical formula is (CH3)2C (C6H4OH)2. Order: 18 Tons Shandong Near Chemical Co., Ltd. View larger video & image Contact Now Hot Sale Bisphenol a CAS No. In the fall of 2014, FDA experts from across the agency, specializing in toxicology, analytical chemistry, endocrinology, epidemiology, and other fields, completed a four-year review of more than 300 scientific studies. Get info of suppliers, manufacturers, exporters, traders of Bisphenol Resin for buying in India. Polycarbonate plastic is used to make critical components of many medical devices and their housings. Bisphenol A epoxy resin is the most common type for concrete coatings because of its excellent adhesion, toughness, abrasion resistance, and chemical resistance. Parents and caregivers can make the personal choice to reduce exposures of their infants and children to BPA: This content is available to use on your website. fatty acid dimers, +undefined-86-13650506873 +undefined-86-13650506873. The National Institute of Environmental Health Sciences (NIEHS) is expanding and accelerating its contributions to scientific knowledge of human health and the environment, and to the health and well-being of people everywhere. Formula: CAS CAS: Chemical Abstract Service Registry Number . [96] The solubility of BPA in water is low (~300g/ton of water)[2] but this is still sufficient to make it a significant means of distribution into the environment. [38][39][40] Spectroscopic data is available from AIST.[41]. 80-05-7 Bisphenol a with Wholesale Price Min. The consensus of major government agencies around the world is that BPA is safe as used in food-contact applications. Toxicol Sci. The oligomers may vary in molecular weight from 340 and higher. [65][24], As a result of the presence of BPA in plastics and other commonplace materials, most people are frequently exposed to trace levels of BPA. Since that time, the FDA has continued to review additional studies as they became available, including those addressing possible low-dose effects. [99] Regardless, the remaining 29% of BPA will continue through to the environment, with low levels of BPA commonly observed in surface water and sediment in the U.S. and Europe. FDAs Studies. Before sharing sensitive information, make sure you're on a federal government site. The degree to which BPA leaches from polycarbonate bottles into liquid may depend more on the temperature of the liquid or bottle, than the age of the container. Singapore 069535, 6,6-Dimethyl-2-methylenebicyclo[3.1.1]heptane, BPA. Alternatively, bisphenol A (BPA) definition is that it is a synthetically obtained colourless crystalline organic compound that occurs in the solid phase belonging to the diphenylmethane group and is soluble in organic solvents but poorly dissolves in water (0.344 % wt. Scientific studies show that in humans BPA is quickly metabolized and eliminated from the body. FDAs regulatory Centers and FDAs National Center for Toxicological Research continue to pursue a set of studies on the fate of BPA in the body from various routes of exposure and the safety of low doses of BPA, including assessing novel endpoints where questions have been raised. [92][101][102] Its half life in water has been estimated at between 4.5 and 15 days, degradation in the air is faster than this, while soil samples degrade more slowly. bisphenol A: [noun] an industrial chemical compound C15H16O2 that is a component especially of hard plastics (such as polycarbonate) and epoxy resins. It is found in various products including shatterproof windows, eyewear, water bottles, and epoxy resins that coat some metal food cans, bottle tops, and water supply pipes. Uses of all substances that migrate from packaging into food, including BPA, are subject to premarket approval by FDA as indirect food additives or food contact substances. Excessive amounts of bisphenol A generate linear high molecular compounds with hydroxyl-, etherand epoxy-terminated groups. This allows exposure to be easily determined by urine testing, facilitating convenient biomonitoring of populations. The results of this study showed no effects of BPA at any dose in the low-dose range. For more chemical safety facts, follow us on social media. NIEHS offers a broad range of job opportunities, career enhancement programs, and research training grants and programs in environmental health sciences and administration. They are produced by the addition of - unsaturated carboxylic acids to epoxy resins. There is some evidence that BPA exposure in infants has decreased as a result of this. This group may lie within the body of the molecule but is usually terminal. People are generally exposed to minute levels of BPA, mostly from the ingestion of food or beverages that have been in contact with materials manufactured with BPA. Is there concern that exposure to BPA can cause harm or result in serious diseases? Lactational transfer of bisphenol A in Sprague-Dawley rats. Federal government websites often end in .gov or .mil. Bisphenol A (BPA) is a chemical building block that is used primarily to make polycarbonate plastics. The hydroxy group may be derived from aliphatic diols, polyols (polyether polyols), phenolic compounds or dicarboxylic acids. Surface chemistry the study of chemical . . Studies are different, and all are not of the same quality. As an addition to this core study, FDA is providing extra animals and tissues to a consortium of grantees [8] selected and funded by the National Institute of Environmental Health Sciences to address other critical questions. This compound is synthesized by the condensation of acetone with phenol. Toxicity evaluation of bisphenol a administered by gavage to sprague dawley rats from gestation day 6 through postnatal day 90. Low oral doses of bisphenol A increase volume of the sexually dimorphic nucleus of the preoptic area in male, but not female, rats at postnatal day 21. [98] Despite its short half-life and non-bioaccumulating character, the continuous release of BPA into the environment causes continuous exposure to both plant[104] and animal life. Extensive scientific dataabout BPA provides consumers with information about BPA safety and help put public confusion about BPA into perspective: If I buy a BPA-free product, is it safer? [74] It binds to both of the nuclear estrogen receptors (ERs), ER and ER. [7] Thus, in bisphenol F, the F signifies formaldehyde. All rights reserved, 2,2-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bis[oxirane],homopoly, 4,4-(1-methylthylidene)bisphenol,polymerwith2,2-[(1-methylethylidene)bis(, Poly(Bisphenol A-co-epichlorohydrin) average Mw ~40,000, pellets, 4-(1-methylethylidene)bisphenol,-polymerwith(chloromethyl)oxirane, bis(4,1-phenyleneoxymethylene)]bis[oxirane], diglycidyletherofbisphenola-basedepoxyresins,lowmolecularweight, lowmolecularweightliquiddgebpa-basedepoxyresins, lowmolecularweightsoliddgebpa-basedepoxyresins, Phenol,4,4-(1-methylethylidene)bis-,polymerwith(chloromethyl)oxirane, phenol,4,4-isopropylidenedi-,dimerwith1-chloro-2,3-epoxypropane, phenol,4,4-isopropylidenedi-,monomerwith1-chloro-2,3-epoxypropane, phenol,4,4-isopropylidenedi-,polymerwith1-chloro-2,3-epoxypropane, phenol,4,4-isopropylidenedi-,tetramerwith1-chloro-2,3-epoxypropane, 2,2-Bis(p-hydroxyphenyl)propane-epichlorohydrin condensate, 2,2-Bis(p-hydroxyphenyl)propane-epichlorohydrin copolymer, 2,2-Bis(p-hydroxyphenyl)propane-epichlorohydrin polymer, 2,2-Diphenylolpropane-epichlorohydrin polymer, 4,4'-ISOPROPYLIDENEDIPHENOL/EPICHLOROHYDRIN COPOLYMER, 4,4-ISOPROPYLIDENEDIPHENOLEPICHLOROHYDRINRESIN, PHENOL44METHYLETHYLIDENEBISPOLYMERWITHCHLOROMETHYLOXIRANE, Reaktionsprodukt aus Bisphenol-A oder -F mit Epichlorhydrin (Molekulargewicht <700, Gehalt an freiem Epichlorhydrin <20 ppm, nicht in R40 oder R45 eingestuft), reaction product: bisphenol-A-(epichlorhydrin) epoxy resin (number average molecular weight 700), bisphenol A/ epichlorohydrin resin, solid, bisphenol A/ epichlorohydrin resin, liquid, BISPHENOL A DIGLYCIDYL ETHER RESIN structure, EPICHLOROHYDRIN-4,4'ISOPROPYLIDENEDIPHENOL RESIN, Bisphenol A epichlorohydrin polymer (25068-38-6), P201-P273-P280-P305+P351+P338-P310-P333+P313-P337+P313-P391, 36/38-43-51/53-42/43-63-62-36/37-20/21/22-45-23/24/25, BISPHENOL A DIGLYCIDYL ETHER RESIN Suppliers, BISPHENOL A DIGLYCIDYL ETHER RESIN(25068-38-6)FT-IR, TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III), 4-[1-hydroxy-2-(4-hydroxyphenyl)propan-2-yl]phenol, 4-[2-(4-hydroxyphenyl)propan-2-yl]phenol: 2-methyloxirane, 4-[1,1,1,3,3,3-Hexafluoro-2-(4-hydroxyphenyl)propan-2-yl]phenol, Phenol, 4,4-(1-methylethylidene)bis-, polymer with (chloromethyl)oxirane, monoesters with C18-unsatd. Regardless, due to the scientific uncertainty, many jurisdictions have taken steps to reduce exposure on a precautionary basis. The studies reviewed were published or available from November 1, 2009 to July 23, 2013. These studies also addressed questions about how long it takes for the body to dispose of BPA. Bisphenol-A Based Epoxy Vinyl Ester Resins Home Bisphenol-A Based Epoxy Vinyl Ester Resins VE resins are a combination of both polyester resin and epoxy resins best properties. 2005 2022 American Chemistry Council, Inc. [74] These interactions are all very weak, but exposure to BPA is effectively lifelong, leading to concern over possible cumulative effects. Bisphenol-F can further link generating tri- and tetra-and higher phenol oligomers. The results, released in 2018 by the U.S. National Toxicology Program, were accompanied by a statement from Dr. Stephen Ostroff, Deputy Commissioner for Foods and Veterinary Medicine at the U. S. Food and Drug Administration (FDA), saying: our initial review supports our determination that currently authorized uses of BPA continue to be safe for consumers.. Epoxy resins are made by reacting epichlorohydrin (ECH) and bisphenol A to produce a different chemical substance called bisphenol A diglycidyl ether (also known as BADGE or DGEBA). The overall health of the world economy will continue to play a major role in future demand for bisphenol A, as its derivatives' major end-use markets include automotive, construction, and electrical/electronic applications. Epoxy Resin Raw Material CAS 106-89-8 Epichlorohydrin 99.9%Min Epichlorohydrin Price, Find Details and Price about Bisphenol-a-Co-Epichlorohydrin 106-89-8 from Epoxy Resin Raw Material CAS 106-89-8 Epichlorohydrin 99.9%Min Epichlorohydrin Price - Shanghai Guanru Chemical Co., Ltd. [9][10] The remaining 5% is used as a major component of several high-performance plastics, and as a minor additive in PVC, polyurethane, thermal paper, and several other materials. The synthesis of diglycidyl ether of bisphenol A (DGEBA), the most widely used epoxy resin monomer, is: 1675-54-3 Chemical Name: BISPHENOL A DIGLYCIDYL ETHER RESIN CBNumber: CB3749115 Molecular Formula: C21H24O4 Molecular Weight: 340.41 MDL Number: MFCD00080480 MOL File: 1675-54-3.mol MSDS File: SDS Modify Date: 2022-12-30 16:20:48 Request For Quotation BISPHENOL A DIGLYCIDYL ETHER RESIN Properties SAFETY 12 oz. bisphenol A type Epoxy resin depending on the molecular weight and degree of polymerization n, the resin is yellow to amber transparent viscous liquid (or solid), the average molecular weight in the production of 300~700, n; 2, softening point below 50 is called low molecular weight epoxy resin (I. E. Soft resin); Molecular weight above 1000, n>2, those having a softening point above 60 C. Advantage Description. Its optical clarity allows direct observation of blood or other fluids to monitor proper flow. BPA is fairly cheap to produce, as the synthesis benefits from a high atom economy and large amounts of both starting materials are available from the cumene process. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. BISPHENOL A DIGLYCIDYL ETHER RESIN Chemical Properties,Uses,Production Introduction Bisphenol A diglycidyl ether (DGEBA) is a pale yellow liquid epoxy compound formed by the polycondensation of epichlorohydrin (ECH) and bisphenol A (BPA). The site is secure. 2012 Jun 1;211(2):114-9. g) Doerge DR, Twaddle NC, Woodling KA, Fisher JW. Due to interest in the exposure to bisphenol A in the community1 and the workplace, OSHA developed a validated method to collect and analyze bisphenol A and diglycidyl ether of bisphenol A. BPS differentiates from BPA by possessing a sulfone group (SO 2) as the central linker of the . BISPHENOL A EPOXY: is solid at room temperature, in the form of prills, white - peal, white to yellow and with a slight phenolic odour. Epoxy resin is based on epichlorhydrin and bisphenol A. From durable sneakers to waterproof jackets, chemistry plays a big role in all types of outdoor activities. Copyright 2022 ChemicalBook. Published September 2022. Some of this is further reacted with methacrylic acid to form bis-GMA, which is used to make vinyl ester resins. When the low-molecular-weight bisphenol A epoxy resin is continuously reacted with bisphenol A, the obtained bisphenol A epoxy resin has a high polymerization with a relative molecular mass 1400 or more. Epoxy is a synthetic resin that uses two chemical components (typically diglycidyl ethers and a combination of bisphenol A and epichlorohydrin) to harden or cure. The CLARITY Study, the largest study ever done on BPA and conducted by FDA experts, confirms that BPA is safe, and supports the agencys one word answer to the question: Is BPA safe?: Yes. In July, 2013, FDA took this action in response to a food additive petition filed by Congressman Edward Markey [10] of Massachusetts. Farbenindustrie reported the coupling of BPA and epichlorohydrin. FDA has amended its regulations to no longer provide for the use of BPA-based polycarbonate resins in baby bottles and sippy cups. [22] The European Chemicals Agency has added BPA to the Candidate List of substances of very high concern (SVHC), which would make it easier to restrict or ban its use in future. [90] Different expression of ERR- in different parts of the body may account for variations in bisphenolA effects. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. Rapid Commun Mass Spectrom. [26] The utilization of BPA further expanded with discoveries at Bayer and General Electric on polycarbonate plastics. Bisphenol A diglycidyl ether (DGEBA) can be called a small-molecule adhesive. Find out about the exciting discoveries being made by NIEHS and NIEHS-supported researchers that are helping to improve health and save lives. Products like bike helmets, police shields, reading glasses and bullet-proof glass are all shatter resistant because of BPA. The epoxide functional group is also collectively called epoxy. Pharmacokinetics of bisphenol A in neonatal and adult rhesus monkeys. Watch Tutorial: How to Select the Best Curing Agent for Epoxy Systems. 2011 Dec 15;207(3):298-305. f) Doerge DR, Twaddle NC, Vanlandingham M, Fisher JW. 250/ Ton Get Latest Price. Some of these studies have raised questions about the safety of ingesting the low levels of BPA that can migrate into food from food contact materials. bisphenol A (BPA), a colourless crystalline solid belonging to the family of organic compounds; its molecular formula is C 15 H 16 O 2. Search for free and find new suppliers for chemical products, pharmaceuticals and APIs. At high concentrations, BPA also binds to and acts as an antagonist of the androgen receptor (AR). [27], In terms of the endocrine disruption controversy, the British biochemist Edward Charles Dodds tested BPA as an artificial estrogen in the early 1930s. Polycarbonate plastic also is used to make housings for electronic products such as cell phones and laptops, as well as optical discs such as CDs and DVDs. Toxicol Lett. Thanks to their high strength, versatility, and excellent adhesion to a variety of surfaces, epoxy resins have gained wide acceptance in diverse applications (coatings, electrical, casting resins, composites, etc.). Find here online price details of companies selling Bisphenol Resin. Scientific research shows that in humans, BPA is quicklymetabolized and eliminated from the body it does not accumulate in blood or tissues. Epoxy groups located at both ends of the molecule can undergo reactions of ring-opening, cross-linking and solidity with amines, anhydrides, and other curing agents of epoxy resins. A resource for kids, parents, and teachers to find fun and educational materials related to health, science, and the environment 2014 May;139(1):4-20. doi: 10.1093/toxsci/kfu021. The molecular structure of bisphenol A epoxy resin contains aromatic rings and lateral hydroxyl groups, which is beneficial to improve adhesion; in addition, the aromatic ring structure also gives the resin higher rigidity, tensile strength and thermal stability; in general, The main characteristics of bisphenol A epoxy type include: fast light curing reaction rate, high hardness and tensile strength after curing, high gloss of the film layer, and excellent chemical corrosion resistance. [43][44] This is achieved by a reaction with epichlorohydrin under basic conditions. [22][17][72], The health effects of BPA have been the subject of prolonged public and scientific debate,[12][13][14] with PubMed listing more than 16,000 scientific papers as of 2022. The manufacturing of epoxy resins and vinyl ester resins account for 25-30% of BPA use. . Transfer to a pear-shaped separatory funnel to separate the liquid, continue washing and separating with deionized water until the solution turns to neutral from alkaline. Heightened interest in the safe use of BPA in food packaging has resulted in increased public awareness as well as scientific interest. Bisphenol S (BPS) is an organic compound with the formula (HOC 6 H 4) 2 SO 2.It has two phenol functional groups on either side of a sulfonyl group. Research studies pursued by FDAs National Center for Toxicological Research have [6]: Found evidence in rodent studies that the level of the active form of BPA passed from expectant mothers to their unborn offspring, following oral exposure, was so low it could not be measured. Scientific Peer-Review of the Draft Assessment of Bisphenol A for Use in Food Contact Applications, 31 October 2008. 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BISPHENOL A DIGLYCIDYL ETHER RESIN,25068-38-6 - Buyers Guide for Chemicals is a directory of chemicals, chemical suppliers and producers. It can also be used in the formation of solid polymeric electrolyte for potential application in electrochemical devices. Phenols can be compounds such as bisphenol A and novolak. Some, but not all, plastics that are marked with recycle codes 3 or 7 may be made with BPA. Food cans and other metal containers may be coated with epoxy resin linings made with BPA to help prevent direct food contact with metal, which helps protect food from contamination and spoilage. Before sharing sensitive information, make sure youre on a federal government site. Polymerisation is achieved by a reaction with phosgene, conducted under biphasic conditions; the hydrochloric acid is scavenged with aqueous base. This results in much lower internal exposure of BPA (i.e., the active form) than what occurs from other routes of exposure such as injection. What is the formula of phenol formaldehyde resin? [91], BPA has been detectable in the natural environment since the 1990s and is now widely distributed. Recently, FDA granted two petitions requesting that FDA amend its food additive regulations to no longer provide for the use of certain BPA-based materials in baby bottles, sippy cups, and infant formula packaging because these uses have been abandoned. These plastics first appeared in 1958, being produced by Mobay, General Electric, and Bayer.